Advanced age increases the risk of developing multiple non-communicable diseases. It is also often accompanied by a loss of intrinsic physiological reserve and decreased resilience to external stressors.
Stem cell Therapy
In the last decade, stem cells are increasingly applied as a therapeutic method for numerous disorders. Stem cell therapy, traditionally applied for hematopoietic disorders, nonetheless, is now established for the treatment of non-hematologic disorders. Accumulating evidence has shown that mesenchymal stem cells (MSCs) offer an encouraging option for cell treatment and reconstruction of human tissues because of their differentiation multipotency, self‐renewal capacity, long‐term ex vivo proliferation, paracrine potentials, and immunoregulatory effect. Furthermore, MSCs have the capability to support the progression and differentiation of other stem cells. They can release bioactive molecules, which is a key benefit in tissue regeneration. These properties result in the progression of treatments for a wide range of diseases, such as diseases affecting the bone, neurons, lung, liver, heart, kidney, etc. Due to these features, it is obvious that MSCs will hold a major therapeutic role in clinical trials. Because of these properties, we provided a general overview of the latest trials that studied the effectiveness of MSCs in several diseases such as neural, liver, kidney, bone, heart diseases and wound healing.
How Does Stem cell Therapy Work?
To date, MSCs have been used to treat many autoimmune diseases, with studies conducted on use for Crohn’s disease, Multiple Sclerosis, Lupus, COPD, Parkinson’s, and more. While MSCs do not provide a cure for these conditions, the premise is allowing the body to heal itself well enough to mitigate the symptoms of the conditions for long periods. In many cases, this alone allows for a substantial increase in the quality of life for patients. If we view aging as a disease and a decrease in organ function we can begin to understand that MSC is rejuvenating our organs and acting not only as a preventative therapy but truly as a way we can improve organ function.
The autoimmune diseases are characterized by overactivation of immune cells, chronic inflammation, and immune response to self-antigens, leading to the damage and dysfunction of multiple organs. Patients still do not receive desired clinical outcomes while suffer from various adverse effects imparted by current therapies. The therapeutic strategies based on mesenchymal stromal cell (MSC) transplantation have become the promising approach for the treatment of autoimmune diseases due to the immunomodulation property of MSCs. MSCs derived from perinatal tissues are collectively known as perinatal MSCs (PMSCs), which can be obtained via painless procedures from donors with lower risk of being contaminated by viruses than those MSCs from adult tissue sources. Therefore, PMSCs may be the ideal cell source for the treatment of autoimmune diseases.
Aging is a balance between entropy (aging or slow breaking down of tissue) and rebuilding (stem cells). If the power of entropy is bigger than the rebuilding abilities of stem cells, this will lead to aging. Aging is also a natural process that our bodies produce in order to regenerate damaged tissue and renew our systems. However, after time, this process starts generating more entropy than rebuilding, which leads to physical, mental, and emotional symptoms that reflect, both on the outside of our body and within, the aging process. Common improvements post-treatment are better quality of sleep, improved skin tone and more energy.